Scientific publications
deCODE is widely recognized as a world leader in the discovery of genes contributing to risk of common diseases. deCODE has also led the way in publishing its discoveries, a commitment that not only drives ongoing research but also enables independent researchers from around the globe to validate the company's discoveries.
deCODE T2™ risk results conferred by each variant are separately derived from the published results of thousands of patients and controls genotyped in the same way (Grant, S.F., et al., Nat Genet, 2006. 38(3): p. 320-3. Steinthorsdottir, V., et al. Nat Genet, 2007. 39: p. 770-776. Zeggini, E., et al., Science, 2007; 316(5829):1336-1341. Saxena, R., et al., Science, 2007, 316(5829):1331-1336. Scott, L.J., et al., Science, 2007;316(5829):1341-1345.Altshuler, D., et al. Nat Genet, 2000. 26(1): p. 76-80) and have been replicated in numerous published studies in a wide variety of populations and ethnic groups.
A list of key publications in regard to reproducibility and clinical relevance includes:
- Grant, et. al., "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes"
(Iceland, Denmark, U.S.)
Nature Genetics 38, 320 - 323 (2006 )
- Wang, J., et al., Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia, 2007; 50:1192-1200
- Scott, L.J., et al., A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants. Science, 2007;316:1341-1345.
- Zeggini, E., et al., Replication of Genome-Wide Association Signals in U.K. Samples Reveals Risk Loci for Type 2 Diabetes. Science, 2007; 316:1336-1341.
- Saxena, R., et al., Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels. Science, 2007; 316:1331-1336.
- Lyssenko, et. al., "Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes"
J. Clin. Invest. 117:2155-2163 (2007).
- Pearson, et. al., "Variation in TCF7L2 Influences Therapeutic Response to Sulfonylureas: A GoDARTs Study"
Diabetes 56: 2178-2182; published online before print as 10.2337/db07-0440
- Pearson ER, D.L., Doney A, , Variation in TCF7L2 influences glycemic response to sulfonylureas. American Diabetes Association 67th Scientific Sessions, 2007.
- Altshuler, D., et al., The common PPAR gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet, 2000. 26: 76-80
- Steinthorsdottir, V., et al., A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet, 2007. 39: 770-776.
- Florez, et. al., "TCF7L2 Polymorphisms and Progression to Diabetes in the Diabetes Prevention Program"
(U.S., multiple ethnicities)
N Engl J Med 2006; 355:241-250
- Humphries, et. al., "Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women" (U.K., multiple ethnicities) Journal of Molecular Medicine: Volume 84, Number 12 / December, 2006: 1005-1014
- Standards of medical care in diabetes--2008. Diabetes Care, 2008. 31 Suppl 1: S12-54.
- Tuomilehto, J., et al., Prevention of type 2 diabetes mellitus by changes in lifestyle among patients with impaired glucose tolerance. N Engl J Med, 2001. 344: 1343-50.
- The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care, 2002. 25: 2165-71.
- Narayan KM et al., Lifetime risk for diabetes mellitus in the United States. JAMA. 2003 Oct 8;290:1884-90.
- Narayan, K.M., et al., Effect of BMI on lifetime risk for diabetes in the U.S. Diabetes Care, 2007. 30: p. 1562-6.
- Crandall, J., et al., The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci, 2006. 61: p. 1075-81.