Scientific publications
deCODE is widely recognized as the world leader in the discovery of genes contributing to risk of common diseases. deCODE has also led the way in publishing its discoveries, a commitment that not only drives ongoing research but also enables independent researchers from around the globe to validate the company's discoveries.
deCODE's discovery of variants on chromosome 9p21 conferring risk of coronary heart disease and MI, published in June 2007, has been replicated in four published studies covering 10 separate populations.
A list of key publications includes (populations/ethnic groups studied noted in parentheses):- Helgadottir et. al., "A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction"
Science 316:1491-1493 (2007) (Iceland, US).
- McPherson, et. al., "A Common Allele on Chromosome 9 Associated with Coronary Heart Disease"
Science 316: 1488-1491 (2007). (Canada, US, Denmark)
- Wellcome Trust Case Control Consortium, "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls"
Nature 447: 661-678 (2007) (England, Scotland and Wales).
- Samani et al., "Genomewide Association Analysis of Coronary Artery Disease"
New England Journal of Medicine 357: 443- 453 (2007) (Great Britain and Germany)
For a complete list of relevant publications, click here.