Scientific publications
deCODE is widely recognized as the world leader in the discovery of genes contributing to risk of common diseases. deCODE has also led the way in publishing its discoveries, a commitment that not only drives ongoing research but also enables independent researchers from around the globe to validate the company’s discoveries. deCODE has published its discoveries of breast cancer risk variants on chromosomes 2, 5, and 16, as well as discovering the concept that many of the common variants are preferentially associated with ER+ breast cancer. These and other studies incorporated into the deCODE BreastCancer™ test have been published extensively in the international scientific press.
For a complete list of relevant and referenced publications, click here.
Stacey SN et al, Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet. 2007 Jul;39(7):865-9. Epub 2007 May 27. PMID: 17529974
Stacey SN, et al. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet. 2008 Jun;40:703-6.
Hunter DJet al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet. 2007 Jul;39(7):870-4. Epub 2007 May 27.PMID: 17529973
Fletcher O, Johnson N, et al.Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):702-5. PMID: 18349290
Gold Bet al. Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4340-5. Epub 2008 Mar 7. PMID: 18326623
Raskin L, et al. FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations. Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1060-5. PMID: 18483326
Garcia-Closas Met al. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet. 2008 Apr 25;4(4):e1000054. PMID: 18437204
Antoniou ACet al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet. 2008 Apr;82(4):937-48. Epub 2008 Mar 20. PMID: 18355772